Event-Related Functional MRI Study on Central Representation of Acute Muscle Pain Induced by Electrical Stimulation

@article{Niddam2002EventRelatedFM,
  title={Event-Related Functional MRI Study on Central Representation of Acute Muscle Pain Induced by Electrical Stimulation},
  author={David M. Niddam and T. C. Yeh and Yu-Te Wu and Po-Lei Lee and L. T. Ho and Lars Arendt-Nielsen and Andrew C. N. Chen and J. C. Hsieh},
  journal={NeuroImage},
  year={2002},
  volume={17},
  pages={1437-1450}
}
Although pathological muscle pain involves a significantly larger population than any other pain condition, the central mechanisms are less explored than those of cutaneous pain. The aims of the study were to establish the pain matrix for muscle pain in the full head volume and, further, to explore the possibility of a functional segregation to nonpainful and painful stimuli within the area of the parasylvian cortex corresponding to the secondary somatosensory area. Additionally, we speculate… 

Figures and Tables from this paper

Discrete changes in cortical activation during experimentally induced referred muscle pain: a single-trial fMRI study.
TLDR
This is the first study to provide evidence of cortical differentiation in the processing of primary and referred pain by inducing muscle pain by hypertonic saline injections into the tibialis anterior or flexor carpi radialis muscle.
Human brain activity associated with painful mechanical stimulation to muscle and bone
TLDR
The putamen and caudate nucleus may have a more significant role in brain processing of muscle pain compared with bone pain in central processing of painful mechanical stimulation to muscle and bone using fMRI.
Central Processing of Acute Muscle Pain in Chronic Low Back Pain Patients: An EEG Mapping Study
  • M. Diers, C. Koeppe, H. Flor
  • Psychology, Medicine
    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
  • 2007
TLDR
Results indicate enhanced perceptual sensitization and enhanced processing of the sensory-discriminative aspect of pain, as expressed in the N80 component, in CLBP patients, and may be related to the affective distress observed in this patient group.
Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects
TLDR
Functional magnetic resonance imaging was used to examine the patterns of cortical activation arising during DOMS-related pain in the quadriceps muscle of healthy volunteers evoked by either voluntary contraction or physical stimulation.
Deactivation of distant pain-related regions induced by 20-day rTMS: a case study of one-week pain relief for long-term intractable deafferentation pain.
TLDR
It is implied that a single session of 20 Hz rTMS over the motor cortex could reduce the pain level in patients suffering from long-term, intractable deafferentation pain.
Primary sensory and motor cortex function in response to acute muscle pain: A systematic review and meta‐analysis
TLDR
The findings of this review indicate reduced S1 and corticomotor activity during and after resolution of acute muscle pain, mechanisms that could plausibly underpin altered sensorimotor function in pain.
...
...

References

SHOWING 1-10 OF 97 REFERENCES
Functional MR imaging analysis of pain-related brain activation after acute mechanical stimulation.
TLDR
The interindividual variability found in this functional MR imaging study calls for repetitive single-subject analysis or more extensive studies of large groups of patients, based on fMR imaging analysis of brain activation after tonic mechanically induced pain.
Central representation of chronic ongoing neuropathic pain studied by positron emission tomography
Expectation of Pain Enhances Responses to Nonpainful Somatosensory Stimulation in the Anterior Cingulate Cortex and Parietal Operculum/Posterior Insula: an Event-Related Functional Magnetic Resonance Imaging Study
TLDR
It is suggested that ACC and PO/PI are involved in modulation of affective aspect of sensory perception by the uncertain expectation of painful stimulus.
Functional MRI study of thalamic and cortical activations evoked by cutaneous heat, cold, and tactile stimuli.
TLDR
Functional magnetic resonance imaging is used to locate discrete regions of the thalamus, insula, and second somatosensory cortex modulated during innocuous and noxious thermal stimulation and provides support for a role of the anterior insula and S2 in the perception of pain; whereas the posterior insula appears to be involved in tactile and innocuous temperature perception.
Pain intensity processing within the human brain: a bilateral, distributed mechanism.
TLDR
Results confirm the existence of a highly distributed, bilateral supraspinal mechanism engaged in the processing of pain intensity and conserve pain intensity information across multiple, functionally distinct brain areas.
Central processing of rectal pain: a functional MR imaging study.
TLDR
The activation patterns observed in this study support the hypothesis that the cerebral processing of visceral pain involves multiple components, similar to the central processing of somatic pain.
A Comparative fMRI Study of Cortical Representations for Thermal Painful, Vibrotactile, and Motor Performance Tasks
TLDR
The study indicates that fMRI enables examination of cortical networks subserving pain perception at an anatomical detail not available with other brain imaging techniques and shows that this cortical network underlying pain perception shares components with the networks underlying touch perception and motor execution.
Non-painful and painful stimulation of human skin and muscle: analysis of cerebral evoked potentials.
Functional MRI of pain- and attention-related activations in the human cingulate cortex.
TLDR
Evidence is provided for a region in the posterior part of the ACC that is involved in pain and a more anterior region involved in other attention-demanding cognitive tasks, which shed light on pain- and attention-related cognitive processes.
...
...