Even without additional therapy, serum thyroglobulin concentrations often decline for years after total thyroidectomy and radioactive remnant ablation in patients with differentiated thyroid cancer.

@article{Padovani2012EvenWA,
  title={Even without additional therapy, serum thyroglobulin concentrations often decline for years after total thyroidectomy and radioactive remnant ablation in patients with differentiated thyroid cancer.},
  author={Ros{\'a}lia do Prado Padovani and Eyal Robenshtok and Matvey Brokhin and Robert Michael Tuttle},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2012},
  volume={22 8},
  pages={778-83}
}
BACKGROUND Current management guidelines suggest that 6-12 months after total thyroidectomy and radioactive iodine remnant ablation (RAI-RA), patients with differentiated thyroid cancer should be re-evaluated with serum thyroglobulin (Tg) and neck ultrasonography to assess the efficacy of initial treatment and to guide subsequent management. However, if serum Tg levels can continue to decline for many years after RAI-RA, then an early assessment of response to therapy could lead to excessive… CONTINUE READING
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AJCC Cancer Staging Manual, Seventh edition

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