Evc regulates a symmetrical response to Shh signaling in molar development.

@article{Nakatomi2013EvcRA,
  title={Evc regulates a symmetrical response to Shh signaling in molar development.},
  author={Mitsushiro Nakatomi and Maria Hovorakova and Amel Gritli-Linde and Helen J. Blair and Katie D. R. Macarthur and Miroslav Peterka and Herv{\'e} Lesot and Renata Peterkova and Victor L. Ruiz-P{\'e}rez and Judith A. Goodship and Heiko Peters},
  journal={Journal of dental research},
  year={2013},
  volume={92 3},
  pages={222-8}
}
Tooth morphogenesis involves patterning through the activity of epithelial signaling centers that, among other molecules, secrete Sonic hedgehog (Shh). While it is known that Shh responding cells need intact primary cilia for signal transduction, the roles of individual cilia components for tooth morphogenesis are poorly understood. The clinical features of individuals with Ellis-van Creveld syndrome include various dental anomalies, and we show here that absence of the cilial protein Evc in… CONTINUE READING
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