Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

  title={Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants},
  author={Michael T Hemann and Anka Bric and Julie Teruya-Feldstein and Andreas Herbst and Jonas Nilsson and Carlos Cordon-Cardo and John L. Cleveland and W P Tansey and Scott W Lowe},
The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effective than wild-type MYC at promoting B cell lymphomagenesis in mice. Mutant MYC proteins retain their ability to stimulate proliferation and activate p53, but are defective at… CONTINUE READING
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