Evasion of alternative complement pathway by Trypanosoma cruzi results from inefficient binding of factor B.

@article{Joiner1986EvasionOA,
  title={Evasion of alternative complement pathway by Trypanosoma cruzi results from inefficient binding of factor B.},
  author={K T Joiner and Alan Sher and Thelma A. Gaither and C T Hammer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 17},
  pages={6593-7}
}
During its differentiation in the insect vector to a stage infective for the mammalian host, Trypanosoma cruzi becomes resistant to lysis by the alternative pathway of complement. To elucidate the mechanism of complement evasion, we studied control of complement activation on the surface of the noninfective epimastigote and the infective culture-derived metacyclic trypomastigote stages (CMT) of T. cruzi. It was found that the predominant form of complement component C3 on epimastigotes is C3b… CONTINUE READING
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