Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma.

  title={Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma.},
  author={Jinu Abraham and Suresh I. Prajapati and Koichi Nishijo and Beverly S. Schaffer and Eri Taniguchi and Aoife Kilcoyne and Amanda T. McCleish and Laura D. Nelon and Francis G. Giles and A. Efstratiadis and Robin D Legallo and Brent M. Nowak and Brian P. Rubin and Suman Malempati and Charles Keller},
  journal={Molecular cancer therapeutics},
  volume={10 4},
Inhibition of the insulin-like growth factor 1 receptor (Igf1r) is an approach being taken in clinical trials to overcome the dismal outcome for metastatic alveolar rhabdomyosarcoma (ARMS), an aggressive muscle cancer of children and young adults. In our study, we address the potential mechanism(s) of Igf1r inhibitor resistance that might be anticipated for patients. Using a genetically engineered mouse model of ARMS, validated for active Igf1r signaling, we show that the prototypic Igf1r… CONTINUE READING
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