Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk

  title={Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk},
  author={Kara N Stevens and Annika Lindblom and Zachary S. Fredericksen and MatthewL. Kosel and V. Shane Pankratz and John L. Hopper and Gillian S. Dite and Carmel Apicella and Melissa C. Southey and Marjanka K Schmidt and Annegein Broeks and Laura J. van ‘t Veer and Rob Aem Tollenaar and Peter A. Fasching and Matthias Wilhelm Beckmann and Alexander Hein and Arif B. Ekici and Neil Johnson and Julian Peto and Isabel Dos Santos Silva and Lorna Gibson and Emily Sawyer and Jos{\'e} Ignacio Abreu P{\'e}rez and Michael John Kerin and Stephen J. Chanock and Jolanta Lissowska and David J. Hunter and Robert Nathaniel Hoover and Gilles D. Thomas and Roger L Milne and Ji Arias Perez and Anna Gonz{\'a}lez-Neira and Javier Benitez and Barbara Burwinkel and Alfons Meindl and Rita Katharina Schmutzler and C R Bartrar and Ute Hamann and Y D Ko and Thomas Br{\"u}ning and Jenny Chang-Claude and Ruediger Hein and Shan Wang-gohrke and Thilo D{\"o}rk and Peter Schuermann and Michael S. Bremer and Peter Hillemanns and Natalia Valerijevna Bogdanova and J V Zalutsky and Ye. I. Rogov and Natalia Antonenkova and Sara J. Margolin and Arto Mannermaa and Vesa Kataja and V. M. Kosma and Jaana M. Hartikainen and Georgia Chenevix-Trench and X Chen and Paolo Peterlongo and Bernardo Bonanni and Laurent Bernard and Siranoush Manoukian and Xiuhai Wang and James R. Cerhan and Celine M. Vachon and Janet E. Olson and Graham G. Giles and Laura Baglietto and Catriona A. McLean and Gianluca Severi and Esther M John and Alexander F Miron and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Il Andrulis and J. A. G. Knight and Ramez Saad Younan and Anna Marie Mulligan and Angela Cox and Ian Wallace Brock and Gemma Elliott and Simon S. Cross and Paul D P Pharoah and Alison M. Dunning and Karen A. Pooley and Manjeet K. Humphreys and Jianpeng Wang and Daehee Kang and K-Y Yoo and D-Y Noh and Suleeporn Sangrajrang and Valerie Gabrieau and Patrick Brennan and James McKay and Hoda Anton-Culver and Argyrios Ziogas and Fergus J. Couch and Douglas F. Easton},
  booktitle={British Journal of Cancer},
Background:Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor receptor-2 overexpression, lymph node metastasis and poor survival. The goal of this study was to evaluate the association between inherited variation in this oncogene and risk of breast cancer.Methods:A single-nucleotide polymorphism from the PIK3CA locus that was associated with… CONTINUE READING


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