Evaluation of urinary pyridinium crosslink excretion as a marker of bone resorption in the rat.

@article{Egger1994EvaluationOU,
  title={Evaluation of urinary pyridinium crosslink excretion as a marker of bone resorption in the rat.},
  author={Christian Egger and Roman C. M{\"u}hlbauer and Rolf Felix and Pierre Dominique Delmas and Sandy C. Marks and Herbert Andre Fleisch},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1994},
  volume={9 8},
  pages={1211-9}
}
The aim of this study was to evaluate the value of the urinary excretion of the pyridinium crosslinks, pyridinoline (Pyr) and deoxypyridinoline (D-Pyr), as markers of bone resorption in the rat. The excretion of the crosslinks was compared with that of urinary [3H]tetracycline ([3H]TC) excretion from chronically [3H]TC-prelabeled animals, a technique established to monitor bone resorption in the rat. Bone resorption was modulated by Ca restriction, infusion of PTH, thyroparathyroidectomy, and… CONTINUE READING

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