Evaluation of two biodegradable nerve guides for the reconstruction of the rat sciatic nerve.


The purpose of this study was to test in vivo two different nerve guides, one of PLGA made of a novel proportion (90:10) of the two polymers, Poly(L-lactide):Poly(glycolide), with (DL-lactide-epsilon-caprolactone) copolyester (Neurolac) tube, in promoting nerve regeneration across a 10 mm-gap of the rat sciatic nerve. Finally, end-to-end coaptation was performed. Motor and sensory functional recovery was assessed throughout the healing period of 20 weeks and the repaired nerves were processed for morphological analysis. Both motor and sensory functions improved significantly in all experimental nerve repair groups, although the rate and extent of recovery was significantly higher in the end-to-end group. No significant differences were detected in the comparison between the two types of tubes. Compatible with results of functional tests, morphological analysis showed that axon regeneration occurred in both PLGA and Neurolac experimental groups but disclosed a different pattern of degradation of the two types of tubes with larger biodegradation of PLGA material by the end of 20 weeks. These results suggest that both types of biomaterial are a good substrate for preparing tubular nerve guides and the different pattern of degradation does not seem to influence the degree of nerve regeneration.

Cite this paper

@article{Lus2007EvaluationOT, title={Evaluation of two biodegradable nerve guides for the reconstruction of the rat sciatic nerve.}, author={Ana L{\'u}cia Lu{\'i}s and Jorge Manuel Gonçalves Rodrigues and Jos{\'e} V Lobato and Maria Ascens{\~a}o Lopes and Sandra Amado and Antonio P. Veloso and Paulo A. S. Armada-da-Silva and Stefania Raimondo and Stefano Geuna and Ant{\^o}nio Alfredo Ferreira and Artur Varej{\~a}o and Jos{\'e} Domingos Santos and Ana Colette Maur{\'i}cio}, journal={Bio-medical materials and engineering}, year={2007}, volume={17 1}, pages={39-52} }