Evaluation of translocator protein quantification as a tool for characterising macrophage burden in human carotid atherosclerosis

@inproceedings{Bird2010EvaluationOT,
  title={Evaluation of translocator protein quantification as a tool for characterising macrophage burden in human carotid atherosclerosis},
  author={J.L.E. Bird and David Izquierdo-Garcia and J. D. Davies and J H F Rudd and K. C. Probst and Nichola L. Figg and J. Clark and P. L. Weissberg and A. P. Davenport and E A Warburton},
  booktitle={Atherosclerosis},
  year={2010}
}
Macrophage presence within atherosclerotic plaque is a feature of instability and a risk factor for plaque rupture and clinical events. Activated macrophages express high levels of the translocator protein/peripheral benzodiazepine receptor (TSPO/PBR). In this study, we investigated the potential for quantifying plaque inflammation by targeting this receptor. TSPO expression and distribution in the plaque were quantified using radioligand binding assays and autoradiography. We show that… CONTINUE READING

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