Evaluation of toluene exposure via drinking water on levels of regional brain biogenic monoamines and their metabolites in CD-1 mice.

@article{Hsieh1990EvaluationOT,
  title={Evaluation of toluene exposure via drinking water on levels of regional brain biogenic monoamines and their metabolites in CD-1 mice.},
  author={Gin C. Hsieh and Raghubir P. Sharma and Robert D. R. Parker and Roger A. Coulombe},
  journal={Ecotoxicology and environmental safety},
  year={1990},
  volume={20 2},
  pages={175-84}
}
Toluene, a potentially neurotoxic substance, is found in trace amounts in groundwater. Adult male CD-1 mice were continuously fed drinking water ad libitum containing 0, 17, 80, and 405 mg/liter toluene. After a 28-day treatment, animals were tested for endogenous levels of the biogenic monoamines norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and their respective metabolites. 3-methoxy-4-hydroxymandelic acid (VMA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and… CONTINUE READING