Evaluation of timefurone, a new anti-atherosclerotic drug, for its effects on lipoprotein cholesterol in male cynomolgus monkeys fed an atherogenic diet for 18 months.

@article{Stevens1985EvaluationOT,
  title={Evaluation of timefurone, a new anti-atherosclerotic drug, for its effects on lipoprotein cholesterol in male cynomolgus monkeys fed an atherogenic diet for 18 months.},
  author={T. Stevens and T. Vidmar and C. E. Day},
  journal={Atherosclerosis},
  year={1985},
  volume={56 3},
  pages={
          301-11
        }
}
  • T. Stevens, T. Vidmar, C. E. Day
  • Published 1985
  • Biology, Medicine
  • Atherosclerosis
  • Forty male cynomolgus monkeys were fed a nutritionally complete diet containing butter and 0.5% cholesterol for 18 months to ensure development of atherosclerosis. Timefurone was administered daily at 10 mg/kg/day. Lipoprotein cholesterol parameters were measured every 4 weeks and clinical chemistries were done at approximately 8-week intervals. Low density lipoprotein cholesterol [LDL-C] was significantly reduced 24-45% at all time periods and total-C was lowered 17-23% at weeks 12, 16, and 24… CONTINUE READING
    4 Citations

    References

    SHOWING 1-10 OF 27 REFERENCES
    High volume screening procedures for hypobetalipoproteinemic activity in rats.
    • 20