Evaluation of timefurone, a new anti-atherosclerotic drug, for its effects on lipoprotein cholesterol in male SEA Japanese quail and rats.

@article{Stevens1985EvaluationOT,
  title={Evaluation of timefurone, a new anti-atherosclerotic drug, for its effects on lipoprotein cholesterol in male SEA Japanese quail and rats.},
  author={T. Stevens and P. E. Schurr and R. B. Gammill and C. E. Day},
  journal={Atherosclerosis},
  year={1985},
  volume={56 3},
  pages={
          313-21
        }
}
  • T. Stevens, P. E. Schurr, +1 author C. E. Day
  • Published 1985
  • Biology, Medicine
  • Atherosclerosis
  • Timefurone was evaluated in several animal models for cholesterol-lowering and anti-atherosclerotic activity. In normal male rats, a dose-response study with timefurone (3, 10, 30, 50 and 100 mg/kg/day) was conducted for 7 days. Significant activity was observed only at 50 and 100 mg/kg/day, where very low and low density lipoprotein cholesterol [(VLDL + LDL)-C] and total-C levels were reduced (mean 27 and 20%). High density lipoprotein cholesterol (HDL-C) was lowered 24% by the high timefurone… CONTINUE READING
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