Evaluation of thyroid gland activity by hormone assays and flow cytometry in rats.

@article{Zbinden1988EvaluationOT,
  title={Evaluation of thyroid gland activity by hormone assays and flow cytometry in rats.},
  author={Gerhard Zbinden},
  journal={Experimental cell biology},
  year={1988},
  volume={56 4},
  pages={196-200}
}
Spontaneous variations in the activity of thyroids and changes induced by methimazole, phenobarbital and 2,4--diaminoanisole sulfate were assessed in rats by repeated measurements of serum T3, T4 and TSH concentrations and cell cycle analysis in isolated nuclei of the thyroids. Methimazole caused a decrease in T3 and T4, and elevation in TSH, reduction of cells in G1 and increase in the percentage of cells in S and G2 phases. With phenobarbital T4 concentrations were decreased, but a mitogenic… CONTINUE READING