Evaluation of thermoresponsive properties and biocompatibility of polybenzofulvene aggregates for leuprolide delivery.

  title={Evaluation of thermoresponsive properties and biocompatibility of polybenzofulvene aggregates for leuprolide delivery.},
  author={Mariano Licciardi and Giovanni Amato and Andrea Cappelli and Marco Paolino and Germano Giuliani and Beatrice Belmonte and Carla Guarnotta and Giovanna Pitarresi and Gaetano Giammona},
  journal={International journal of pharmaceutics},
  volume={438 1-2},

Physicochemical Properties of a New PEGylated Polybenzofulvene Brush for Drug Encapsulation

The photo-physical features of poly-6-MOEG-9-T-BF3k-FE could allow the biodistribution of the resulting drug delivery systems to be monitored by fluorescence microscopy techniques, and showed an interesting cytocompatibility in the whole concentration range tested.

Design and development of hyaluronan-functionalized polybenzofulvene nanoparticles as CD44 receptor mediated drug delivery system

The ability of doxorubicin-loaded TCPB nanoparticles (DOXO-TCPB) to be internalized into cancer cells by CD44 receptor mediated uptake was assessed by means of uptake studies in HCT cells.

Densely PEGylated Polybenzofulvene Brushes for Potential Applications in Drug Encapsulation

The obtained results make these PEGylated polybenzofulvene brushes (PPBFB) derivatives potentially useful as nanocarriers for nanoencapsulation and delivery of drug molecules.

Cyclodextrin-Adamantane Host–Guest Interactions on the Surface of Biocompatible Adamantyl-Modified Glycodendrimers

The host–guest interaction features of the maltosylated dense shell glycodendrimer along with the low cytotoxicity provided the rational basis for the use of these adamantyl-functionalized gly codendrimers in the design of supramolecular systems potentially threatening steric hindrance.

Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

This biomimetic multifunctional material bearing HA on the surface of its cylindrical brush architecture showed promising prerequisites for the preparation of nanostructured drug delivery systems.

A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering

Property of stimuli-responsive hydrogel systems enhance cellular responses and cell distribution at any site prior to the transitional phase leading to gelation, which allows significant simulation of the extracellular matrix (ECM), due to its similar structural properties.

Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules

This review summarizes the contribution of functionalized polymers to enhance oral bioavailability of sensitive molecules and their application status in medicine for different diseases.

A Novel Approach toward Polyfulvene: Cationic Polymerization of Enediynes

Enediyne compounds have found limited applications in polymer science and material chemistry due to the poor regioselectivity and/or the step-growth nature in their radical polymerizations. However,



PEG-benzofulvene copolymer hydrogels for antibody delivery.

Synthesis and characterization of biocompatible thermo-responsive gelators based on ABA triblock copolymers.

These novel triblock copolymers are water-soluble in dilute aqueous solution at 20 degrees C and pH 7.4 but form free-standing physical gels at 37 degrees C due to hydrophobic interactions between the poly(N-isopropylacrylamide) blocks; this suggests possible applications in drug delivery and tissue engineering.

Sulfonamide-based pH- and temperature-sensitive biodegradable block copolymer hydrogels.

Since changes in temperature do not induce gel formation in this pH- and temperature-sensitive block copolymer solution, this hydrogel can be employed as an injectable carrier using a long guide catheter into the body and make the OSM-PCLA-PEG-P CLA-OSM hydrogels an ideal candidate for use as an injected carrier for certain protein-based drugs known to denature in low-pH environments.

Structure-property relationships in densely grafted π-stacked polymers

Three methyl end-capped oligo(ethylene glycol) (MOEG) ethers (1b-d) and a methoxyderivative (1a) of benzofulvene monomer BF3k were synthesized and induced to polymerize spontaneously by solvent

New π‐stacked benzofulvene polymer showing thermoreversible polymerization: Studies in macromolecular and aggregate structures and polymerization mechanism

The macromolecular and aggregate structures of poly[ethyl 1-methylene-3-(4-methylphenyl)-1H-indene-2-carboxylate] (poly-BF1; a new polymer based on a functionalized benzofulvene moiety showing

Self-assembly and adhesion of DOPA-modified methacrylic triblock hydrogels.

Oxidation of DOPA groups, a process that is greatly accelerated at a pH of 10, decreased the adhesive performance of the hydrogels even further, and hydrophilic and highly swellable, but less adhesive gels were formed.

Rheology and Drug Release Properties of Bioresorbable Hydrogels Prepared from Polylactide/Poly(ethylene glycol) Block Copolymers

Ring-opening polymerization of L(D)-lactide was realized in the presence of poly(ethylene glycol) (PEG), yielding PLLA/PEG and PDLA/PEG block copolymers. Bioresorbable hydrogels were prepared from

A Temperature-Responsive Copolymer Hydrogel in Controlled Drug Delivery

A novel optical transition for a hydrogel of polyacrylamide and poly(acrylic acid) random copolymer was observed. The poly(acrylamide-co-acrylic acid) hydrogel is opaque white at low temperature,

Biodegradable microspheres for protein delivery.

  • V. SinhaA. Trehan
  • Biology
    Journal of controlled release : official journal of the Controlled Release Society
  • 2003

Synthesis and Rheological Behavior of New Hydrophobically Modified Hydrogels with Tunable Properties

New hydrophobically modified hydrogels have been designed in order to obtain a series of gels with identical elastic moduli but variable dissipative properties. The synthesis of these systems has