Evaluation of the xenobiotic biotransformation capability of six rodent hepatoma cell lines in comparison with rat hepatocytes

@article{Donato1994EvaluationOT,
  title={Evaluation of the xenobiotic biotransformation capability of six rodent hepatoma cell lines in comparison with rat hepatocytes},
  author={Mar{\'i}a Teresa Donato and Anna Maria Bassi and M. Jos{\'e} G{\'o}mez-lech{\'o}n and Susanna Penco and Elisa H Herrero and Donatella Adamo and Jose V Castell and Margherita Ferro},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={1994},
  volume={30},
  pages={574-580}
}
Phase I and II activities were examined in six rodent hepatoma cell lines and compared with those of cultured rat hepatocytes both in basal conditions and after exposure to 5µM methylcholanthrene, 2 mM phenobarbital, and 15µMβ-naphtoflavone. The metabolic profile of testosterone was also studied. The highest aryl hydrocarbon hydroxylase and 7-ethoxycoumarinO-deethylase activities were found in MH1C1 cells. Comparable values for 7-ethoxyresorufinO-deethylase activity, ranging from 21.6 to 42.9… CONTINUE READING