Evaluation of the usefulness of biomarkers for cardiac and skeletal myotoxicity in rats.

  title={Evaluation of the usefulness of biomarkers for cardiac and skeletal myotoxicity in rats.},
  author={Yutaka Tonomura and Yoko Mori and Mikinori Torii and Takeki Uehara},
  volume={266 1-3},
Since cardiac and skeletal myotoxicity affect the development of drug candidates, it is important to detect their toxicity at an early stage of drug development. For that purpose, in this study, the usefulness of several cardiac and skeletal myotoxic biomarkers in blood were evaluated using two rat models treated intraperitoneally with an acetylcholinesterase inhibitor carbofuran (CAF) or a synthetic catecholamine isoproterenol (ISO). The biomarkers assayed were fatty acid binding protein 3… CONTINUE READING


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