Evaluation of the uncertainty in an oral reference dose for methylmercury due to interindividual variability in pharmacokinetics.

@article{Clewell1999EvaluationOT,
  title={Evaluation of the uncertainty in an oral reference dose for methylmercury due to interindividual variability in pharmacokinetics.},
  author={Harvey J. Clewell and Jeffery Gearhart and Patrick R. Gentry and Tammie R. Covington and C B VanLandingham and Kenny S. Crump and Annette M. Shipp},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  year={1999},
  volume={19 4},
  pages={547-58}
}
An analysis of the uncertainty in guidelines for the ingestion of methylmercury (MeHg) due to human pharmacokinetic variability was conducted using a physiologically based pharmacokinetic (PBPK) model that describes MeHg kinetics in the pregnant human and fetus. Two alternative derivations of an ingestion guideline for MeHg were considered: the U.S. Environmental Protection Agency reference dose (RfD) of 0.1 microgram/kg/day derived from studies of an Iraqi grain poisoning episode, and the… CONTINUE READING
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