Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a 4-week study in CD-1 mice.

@article{Henry1997EvaluationOT,
  title={Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a 4-week study in CD-1 mice.},
  author={Scott P. Henry and Jason T Taylor and Louise Midgley and Arthur A. Levin and Douglas J. Kornbrust},
  journal={Antisense & nucleic acid drug development},
  year={1997},
  volume={7 5},
  pages={473-81}
}
The subchronic toxicity of ISIS 2302 and ISIS 3082, phosphorothioate oligonucleotides with antisense activity against human and murine ICAM-1 mRNA, respectively, was investigated in CD-1 mice. ISIS 2302 is currently in clinical trials as an anti-inflammatory agent. Because of the differences in mRNA sequence targets between humans and mice, ISIS 2302 has no pharmacologic activity in mice. ISIS 3082 was specifically designed to inhibit murine ICAM-1 and was included in this study to evaluate the… CONTINUE READING
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