Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A. Basis for distinct durations of inhibition of exocytosis in central neurons.

@article{Foran2003EvaluationOT,
  title={Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A. Basis for distinct durations of inhibition of exocytosis in central neurons.},
  author={Patrick G Foran and Nadiem Mohammed and Godfrey O Lisk and Sharuna Nagwaney and Gary W. Lawrence and Eric Johnson and Leonard B Smith and Kei Roger Aoki and J Oliver Dolly},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 2},
  pages={1363-71}
}
Seven types (A-G) of botulinum neurotoxin (BoNT) target peripheral cholinergic neurons where they selectively proteolyze SNAP-25 (BoNT/A, BoNT/C1, and BoNT/E), syntaxin1 (BoNT/C1), and synaptobrevin (BoNT/B, BoNT/D, BoNT/F, and BoNT/G), SNARE proteins responsible for transmitter release, to cause neuromuscular paralysis but of different durations. BoNT/A paralysis lasts longest (4-6 months) in humans, hence its widespread clinical use for the treatment of dystonias. Molecular mechanisms… CONTINUE READING
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