Evaluation of the suppressive actions of glucosamine on the interleukin-1β-mediated activation of synoviocytes

@article{Hua2007EvaluationOT,
  title={Evaluation of the suppressive actions of glucosamine on the interleukin-1$\beta$-mediated activation of synoviocytes},
  author={Jianyi Hua and Koji Sakamoto and Tadahiro Kikukawa and Chiyuki Abe and Hisashi Kurosawa and Isao Nagaoka},
  journal={Inflammation Research},
  year={2007},
  volume={56},
  pages={432-438}
}
Abstract.Objective:Recently, we found that administration of glucosamine to adjuvant arthritis, a model for rheumatoid arthritis, suppressed the progression of arthritis in rats. To clarify its anti-inflammatory mechanism, we evaluated the actions of glucosamine on the activation of synoviocytes in vitro.Materials and methods:Synoviocytes isolated from human synovial tissues were stimulated with interleukin (IL)-1β in the presence of 0.01–1 mM glucosamine. IL-8 and prostaglandin (PG) E2 were… Expand
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