Evaluation of the subchronic and reproductive effects of a series of chlorinated propanes in the rat. II. Toxicity of 1,2,2,3-tetrachloropropane and 1,1,2,2,3-pentachloropropane.

@article{Johannsen1988EvaluationOT,
  title={Evaluation of the subchronic and reproductive effects of a series of chlorinated propanes in the rat. II. Toxicity of 1,2,2,3-tetrachloropropane and 1,1,2,2,3-pentachloropropane.},
  author={Frederick R. Johannsen and George J. Levinskas and George M. Rusch and James B. Terrill and Raymond E. Schroeder},
  journal={Journal of toxicology and environmental health},
  year={1988},
  volume={25 3},
  pages={
          317-28
        }
}
Comparative subchronic and reproductive toxicity studies by inhalation exposure were conducted with 1,2,2,3-tetrachloropropane (TECP) and 1,1,2,2,3-pentachloropropane (PCP). Groups of 5 male and 5 female CD rats were exposed 6 h/d, 5 d/wk for 4 wk to either TECP or PCP at target concentrations of 0, 100, 300, 600, or 900 ppm (single exposure only). Deaths occurred at and above 300 ppm PCP and 600 ppm TECP. Significant irritation of mucosal tissue was attributed to vapors of TECP and PCP. Lower… 
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Subchronic inhalation toxicity of the chlorinated propane 1,1,1,3,3,3-hexachloropropane (HCC-230fa).
TLDR
Exposure to HCC-230fa did not significantly alter the primary humoral immune response to sheep red blood cell (SRBC) and the no-observed-adverse-effect level (NOAEL) was considered to be 2.5 ppm.
Developmental toxicity and genotoxicity studies of 1,1,1,3,3,3-hexachloropropane (HCC-230fa) in rats.
TLDR
The results of these studies suggest that HCC-230fa affects rapidly dividing cells and may have long-term consequences for occupational exposures.
Developmental Toxicity and Genotoxicity Studies of
TLDR
Evidence of maternal and developmental toxicity was observed at 25 ppm and was noted as significant, compound-related reductions in mean maternal body weight, weight change, and food consumption and significant fetal effects also were observed.

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