Evaluation of the somatogenic activity of bovine placental lactogen with cell lines transfected with the bovine somatotropin receptor.

@article{Warren1999EvaluationOT,
  title={Evaluation of the somatogenic activity of bovine placental lactogen with cell lines transfected with the bovine somatotropin receptor.},
  author={Wesley C. Warren and John C. Byatt and Megan Huynh and K Paik and G. J. Pegg and Nicholas R. Staten},
  journal={Life sciences},
  year={1999},
  volume={65 25},
  pages={
          2755-67
        }
}
Studies have shown that bovine placental lactogen (bPL) has partial somatogenic activity in vivo even though binding results clearly indicate bPL does not cause homodimerization of the bovine somatotropin receptor (bST-R). To help understand the receptor binding versus biological activity of bovine somatotropin (bST) and bPL we have developed a homologous model system. Full length bST-R was stably transfected into a murine lymphoid cell line, Ba/F3 and a hamster kidney cell line, BHK. From both… CONTINUE READING
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