Evaluation of the skin sensitization potential of chemicals using expression of co-stimulatory molecules, CD54 and CD86, on the naive THP-1 cell line.

@article{Yoshida2003EvaluationOT,
  title={Evaluation of the skin sensitization potential of chemicals using expression of co-stimulatory molecules, CD54 and CD86, on the naive THP-1 cell line.},
  author={Yukiko Yoshida and Hitoshi Sakaguchi and Yuichi Ito and Masahiro Okuda and Hiroyuki Suzuki},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2003},
  volume={17 2},
  pages={
          221-8
        }
}
It has been known that dendritic cells (DCs) including Langerhans cells (LCs) play a critical role in the skin sensitization process. Many attempts have been made to develop in vitro sensitization tests that employ DCs derived from peripheral blood mononuclear cells (PBMC-DC) or CD34+ hematopoietic progenitor cells (CD34+ HPC) purified from cord blood or bone marrow. However, the use of the DCs in in vitro methods has been difficult due to the nature of these cells such as low levels in the… CONTINUE READING
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