Evaluation of the sensory irritation test for the assessment of occupational health risk.

@article{Bos1991EvaluationOT,
  title={Evaluation of the sensory irritation test for the assessment of occupational health risk.},
  author={Peter M. J. Bos and Albert Zwart and P G Reuzel and Peter C. Bragt},
  journal={Critical reviews in toxicology},
  year={1991},
  volume={21 6},
  pages={
          423-50
        }
}
Many occupational exposure limits (OELs) are based on irritation. A sensory irritation test has been developed based on trigeminal nerve stimulation in the nasal mucosa of rodents which results in a decreased respiratory frequency. The RD50, the concentration inducing a 50% decrease in the respiratory rate, was proposed for the assessment of OELs. The reproducibility within one laboratory appeared to be satisfactory, but interlaboratory differences may be larger. Intra- and interspecies… CONTINUE READING

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