Evaluation of the sensitivity of R1ρ MRI to pH and macromolecular density

@inproceedings{Ali2019EvaluationOT,
  title={Evaluation of the sensitivity of R1ρ MRI to pH and macromolecular density},
  author={Syed O Ali and Petros Fessas and Joshua D. Kaggie and Fulvio Zaccagna and Gavin Houston and Scott A. Reid and Martin J. Graves and Ferdia A. Gallagher},
  booktitle={Magnetic resonance imaging},
  year={2019}
}
The tumor microenvironment is characteristically acidic and this extracellular acidosis is known to play a role in carcinogenesis and metastasis and can affect tumor chemosensitivity and radiosensitivity. Intracellular pH has been used as a possible biomarker of salvageable tissue in ischemic stroke. A non-invasive MRI-based approach for the determination and imaging of cerebral pH would be a powerful tool in cancer diagnosis and monitoring, as well as stroke treatment planning. Several pH… CONTINUE READING
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