Evaluation of the role of phosphatidylserine translocase activity in ABCA1-mediated lipid efflux.

@article{Smith2002EvaluationOT,
  title={Evaluation of the role of phosphatidylserine translocase activity in ABCA1-mediated lipid efflux.},
  author={Jonathan D Smith and Christine A Waelde and Andrew Horwitz and Ping Zheng},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 20},
  pages={17797-803}
}
The following two theories for the mechanism of ABCA1 in lipid efflux to apolipoprotein acceptors have been proposed: 1) that ABCA1 directly binds the apolipoprotein ligand and then facilitates lipid efflux and 2) that ABCA1 acts as a phosphatidylserine (PS) translocase, increasing PS levels in the plasma membrane exofacial leaflet, and that this is sufficient to facilitate apolipoprotein binding and lipid assembly. Upon induction of ABCA1 in RAW264.7 cells by cAMP analogues there was a… CONTINUE READING

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