Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model.

@article{Kovoor2001EvaluationOT,
  title={Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model.},
  author={Pramesh Kovoor and Kevin Wickman and Colin T. Maguire and Wenji Pu and Josef Gehrmann and Charles I. Berul and David E Clapham},
  journal={Journal of the American College of Cardiology},
  year={2001},
  volume={37 8},
  pages={2136-43}
}
OBJECTIVES We sought to study the role of I(KACh) in atrial fibrillation (AF) and the potential electrophysiologic effects of a specific I(KACh) antagonist. BACKGROUND I(KACh) mediates much of the cardiac responses to vagal stimulation. Vagal stimulation predisposes to AF, but the specific role of I(KACh) in the generation of AF and the electrophysiologic effects of specific I(KACh) blockade have not been studied. METHODS Adult wild-type (WT) and I(KACh)-deficient knockout (KO) mice were… CONTINUE READING
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The Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group. Dofetilide in patients with congestive heart failure and left ventricular dysfunction

  • C Torp-Pedersen, M Moller, PE Bloch-Thomsen
  • N Engl J Med 1999;341:857–65
  • 2001
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