Evaluation of the rodent micronucleus assay by a 28-day treatment protocol: Summary of the 13th Collaborative Study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Environmental Mutagen Society of Japan (JEMS)-Mammalian Mutagenicity Study Group (MMS).

@article{Hamada2001EvaluationOT,
  title={Evaluation of the rodent micronucleus assay by a 28-day treatment protocol: Summary of the 13th Collaborative Study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Environmental Mutagen Society of Japan (JEMS)-Mammalian Mutagenicity Study Group (MMS).},
  author={Shuichi Hamada and Shizuyo Sutou and Takeshi Morita and Akihiro Wakata and Shougo Asanami and Satoshi Hosoya and Shigenari Ozawa and Koji Kondo and Madoka Nakajima and Hiroyasu Shimada and Kayo Kumar Osawa and Yasushi Kondo and Norihide Asano and Seiichi Sato and Hiroshi Tamura and Nobuhiro Yajima and Richard Marshall and Claudia B Moore and David H. Blakey and Leonard M. Schechtman and J L Weaver and Dorothea K. Torous and Raymond Proudlock and Shinobu Ito and Chiaki Namiki and Makoto Hayashi},
  journal={Environmental and molecular mutagenesis},
  year={2001},
  volume={37 2},
  pages={93-110}
}
To examine whether micronucleus tests can be incorporated into general toxicology assays, we performed micronucleus tests applying the treatment protocols typically used in such assays. In this 13th Collaborative Study of the CSGMT, both rats and mice were tested, although rats were used in the majority of the studies. Fifteen mutagens were tested in rats, mainly by oral (p.o.) administration. Micronucleus induction was evaluated 2, 3, and 4 days, and 1, 2, 3, and 28 days after the beginning of… CONTINUE READING