Evaluation of the rhodopsin knockout mouse as a model of pure cone function.

  title={Evaluation of the rhodopsin knockout mouse as a model of pure cone function.},
  author={Gesine Bettina Jaissle and Christian Albrecht May and Jacqueline Reinhard and K. Kohler and Sascha Fauser and Elke L{\"u}tjen-Drecoll and Eberhart Zrenner and Mathias Wolfgang Seeliger},
  journal={Investigative ophthalmology & visual science},
  volume={42 2},
PURPOSE To determine a time window in the rhodopsin knockout (Rho(-/-)) mouse during which retinal function is already sufficiently developed but cone degeneration is not yet substantial, thus representing an all-cone retina. METHODS Electroretinograms (ERGs) were obtained from 14 homozygous Rho(-/-) mice and eight C57Bl/6 control mice. The same individuals were tested every 7 days, beginning as early as postnatal day (P)14. The ERG protocols included flash and flicker stimuli, both under… CONTINUE READING


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