Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy

@article{Vurucu2008EvaluationOT,
  title={Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy},
  author={Sebahattin Vurucu and Erkan Demirkaya and Mustafa Kul and Bulent Unay and Davut Gul and Rıdvan Akın and Erdal Gokçay},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2008},
  volume={32},
  pages={844-848}
}

Tables from this paper

Methylenetetrahydrofolate reductase gene polymorphism and clinical importance in epilepsy patients using valproic acid, carbamazepine and levetiracetam

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Relationship between antiepileptic drugs and biological markers affecting long-term cardiovascular function in children and adolescents.

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The cardiovascular effects of anticonvulsant therapy and their use in childhood epilepsy with special reference to homocysteine and lipoprotein is reviewed, prompting concerns about the long-term implications of chronic AED use in children and cardiovascular risk.

Effect of carbamazepine therapy on homocysteine, vitamin B12 and folic acid levels in children with epilepsy

6 months of carbamazepine therapy did not cause significant change in serum levels of homocysteine, vitamin B12 and folic acid, and there was no effect of age, sex or dietary pattern on homocy steine levels.

Interictal epileptiform discharges on electroencephalography in children with methylenetetrahydrofolate reductase (MTHFR) polymorphisms

There was no increase in the prevalence of interictal epileptiform discharges in seizure-free and asymptomatic children with MTHFR C677T and A1298C polymorphisms.

Is There a Relation between 677C>T Polymorphism in the MTHFR Gene and the Susceptibility to Epilepsy in Young Patients? A Meta-Analysis

The meta-analysis revealed that the carrier state for the T allele as well as the TT genotype of the MTHFR 677C>T polymorphism increases the risk of epilepsy in young adults but not in children.

Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs

Long-term use of antiepileptic drugs, especially old-generation polytherapy, can increase lipid profiles, homocysteine levels, ADMA, and carotid intima-media thickness compared to the minimal effect of new AEDs.

References

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Correlation of the C677T MTHFR genotype with homocysteine levels in children with sickle cell disease.

This study failed to demonstrate an elevation in plasma Hcy levels in children with SCD compared with normal controls, and hyperhomocysteinemia did not seem to be a significant factor in the pathogenesis of stroke in childrenwith sickle cell disease.

The effect of B-vitamins on hyperhomocysteinemia in patients on antiepileptic drugs

The 677T genotype of the common MTHFR thermolabile variant and fasting homocysteine in childhood venous thrombosis

Data of this childhood case-control study suggest that mildly elevated fasting homocysteine concentrations >8.3 μmol/l and the CT genotype of the MTHFR C677T variant are significant risk factors for venous vascular occlusion in children.

Hyperhomocysteinemia Is Associated With Low Plasma Pyridoxine Levels in Children With Sickle Cell Disease

The data suggest that children with SCD have significant hyperhomocysteinemia, associated with pyridoxine and relative folate deficiencies, as well as a significant negative correlation with PML homocysteine levels.

Hyperhomocysteinemia in children with renal transplants

It is concluded that a moderate degree of hyperhomocysteinemia is often present in renal transplant children and that folate supplementation must be considered in this population.

Folate, homocysteine and methionine loading in patients on carbamazepine

The methionine loading test identified additional patients with hyperhomocysteinemia undetected by fasting p‐tHcy in patients on carbamazepine (CBZ), suggesting CBZ therapy may be associated with low folate and high p‐ tHcy levels.