Evaluation of the reinforcing properties and phencyclidine-like discriminative stimulus effects of dextromethorphan and dextrorphan in rats and rhesus monkeys

@article{Nicholson1999EvaluationOT,
  title={Evaluation of the reinforcing properties and phencyclidine-like discriminative stimulus effects of dextromethorphan and dextrorphan in rats and rhesus monkeys},
  author={Katherine L. Nicholson and Belinda A. Hayes and Robert L. Balster},
  journal={Psychopharmacology},
  year={1999},
  volume={146},
  pages={49-59}
}
Abstract Rationale: Dextromethorphan (DXM) and its metabolite, dextrorphan (DXO) have neuroprotective and anticonvulsant properties through their activity as N-methyl-d-aspartate (NMDA) receptor channel blockers. Based on this receptor activity, coupled with reports of DXM abuse, both were evaluated for abuse potential and phencyclidine (PCP)-like behavioral effects in two animal models. Objectives and methods: The discriminative stimulus properties of DXO and DXM were tested in rats (3–56 mg… 

The phencyclidine-like discriminative stimulus effects and reinforcing properties of the NR2B-selective N-methyl-D-aspartate antagonist CP-101 606 in rats and rhesus monkeys

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Comparative effects of dextromethorphan and dextrorphan on nicotine discrimination in rats

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Results show that combinations of DEX and DIP have stimulant properties and are self-administered by animals, an effect that was significantly enhanced when DIP was given in combination with DEX.

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TLDR
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TLDR
The results demonstrate that the cellular actions of the individual channel-blocking NMDA antagonists, in particular affinity for the channel site and NMDA receptor specificity, are important determinants of their discriminative stimulus effects.

The selective glycine antagonist gavestinel lacks phencyclidine-like behavioral e¡ects

TLDR
Results suggest that at behaviorally active doses gavestinel is not PCPlike and is likely to have low abuse liability.

Evaluation of the discriminative stimulus effects of the low-affinity N-methyl-D-aspartate channel blockers AR-R 13950AA and AR-R 16283AA in rats and rhesus monkeys.

TLDR
The results with AR-R 16283AA in monkeys suggest that, at doses above therapeutic levels, it may produce PCP-like intoxication in humans, and there is some overlap of the discriminative stimulus effects produced by the AR- R compounds with those of PCP, but there are also important differences.

REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats

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...

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