Evaluation of the procoagulant activity of endogenous phospholipids in the platelet-free plasma of children with sickle cell disease using functional assays.

@article{Noubouossie2012EvaluationOT,
  title={Evaluation of the procoagulant activity of endogenous phospholipids in the platelet-free plasma of children with sickle cell disease using functional assays.},
  author={Denis C F Noubouossie and Phu-Quoc L{\^e} and Laurence Rozen and France Debaugnies and Alina Ferster and Anne Claire Demulder},
  journal={Thrombosis research},
  year={2012},
  volume={130 2},
  pages={259-64}
}
BACKGROUND The mechanisms of hypercoagulability in sickle cell disease (SCD) are poorly understood. OBJECTIVE We aimed to explore the procoagulant activity of endogenous phospholipids (ePL) in the platelet-free plasma of SCD children. METHODS A factor Xa clotting time (XACT), thrombin generation (TG) and a capture-based assay for the detection of procoagulant microparticles (PMP) were used. Forty three SCD children (35 SS, 6 SC and 2 Sβ+) were evaluated at steady-state and compared to 20… CONTINUE READING
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Clinical evaluation of a new functional test for detection of plasma procoagulant phospholipids

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