Evaluation of the potential role of cytokines in toxic epidermal necrolysis.

  title={Evaluation of the potential role of cytokines in toxic epidermal necrolysis.},
  author={Amal Nassif and Homayoun Moslehi and Sabine le Gouvello and Martine Bagot and Luc Lyonnet and L Michel and Laurence Boumsell and Armand Bensussan and J. C. Roujeau},
  journal={The Journal of investigative dermatology},
  volume={123 5},
Toxic epidermal necrolysis is a rare disease observed as a consequence of adverse reactions to drugs. It results in the widespread apoptosis of epidermal cells and has a high mortality rate. The mechanisms leading to this apoptosis are not yet elucidated. We investigated whether the cytokines present in the blister fluid, which accumulates under necrotic epidermis, originated from T lymphocytes and may play a role in the propagation of keratinocyte apoptosis. Interferon gamma (IFN-gamma… CONTINUE READING


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