Evaluation of the potential of triethanolamine to alter hepatic choline levels in female B6C3F1 mice.

@article{Stott2004EvaluationOT,
  title={Evaluation of the potential of triethanolamine to alter hepatic choline levels in female B6C3F1 mice.},
  author={William T Stott and Birgit Radtke and V. Ann Linscombe and M Mar and Steven H Zeisel},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2004},
  volume={79 2},
  pages={242-7}
}
Triethanolamine (TEA), a widely used nongenotoxic alcohol-amine, has recently been reported to cause an increased incidence of liver tumors in female B6C3F1 mice, but not in males nor in Fischer 344 rats. Choline deficiency induces liver cancer in rodents, and TEA could compete with choline uptake into tissues. The potential of TEA to cause choline deficiency in the liver of these mice as a mode of tumorigenesis was investigated. Groups of female B6C3F1 mice were administered 0 (vehicle) or a… CONTINUE READING
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