Evaluation of the potential impact of age- and gender-specific lung morphology and ventilation rate on the dosimetry of vapors.

@article{Sarangapani2003EvaluationOT,
  title={Evaluation of the potential impact of age- and gender-specific lung morphology and ventilation rate on the dosimetry of vapors.},
  author={Ramesh Sarangapani and Patrick R. Gentry and Tammie R. Covington and Justin G. Teeguarden and Harvey J. Clewell},
  journal={Inhalation toxicology},
  year={2003},
  volume={15 10},
  pages={987-1016}
}
In recent years, there have been growing concerns that due to differences, both pharmacokinetic and pharmacodynamic, between children and adults, children could be at greater risk of adverse effects following chemical exposure. The specific goal of this study was to demonstrate an approach for using physiologically based pharmacokinetic (PBPK) modeling to compare inhalation dosimetry in the adult and the child of both males and females. Three categories of gases were considered: rapidly and… CONTINUE READING
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