Evaluation of the phencyclidine-like discriminative stimulus effects of novel NMDA channel blockers in rats

  title={Evaluation of the phencyclidine-like discriminative stimulus effects of novel NMDA channel blockers in rats},
  author={Katherine L. Nicholson and Robert L. Balster},
RationaleBecause of their potential therapeutic effects, N-methyl-d-aspartate (NMDA) receptor antagonists have been investigated for clinical use. Unfortunately, many channel-blocking antagonists have been associated with the production of side effects, including motor impairment and phencyclidine (PCP)-like subjective effects.ObjectiveThis study investigated the relationship between NMDA receptor channel blockade and production of PCP-like side effects by evaluating a variety of NMDA channel… 

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NMDA Receptors Containing the GluN2D Subunit Control Neuronal Function in the Subthalamic Nucleus

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1-Methyl-1,2,3,4-Tetrahydroisoquinoline, an Endogenous Amine with Unexpected Mechanism of Action: New Vistas of Therapeutic Application

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1-Methyl-1,2,3,4-Tetrahydroisoquinoline: A Potent Neuroprotecting Agent

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Phencyclidine-like discriminative stimulus properties of MK-801 in rats.

Clinically available NMDA receptor antagonists memantine and dextromethorphan reverse existing tolerance to the antinociceptive effects of morphine in mice

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