Evaluation of the pharmacokinetic profile and analgesic efficacy of oral morphine after total hip arthroplasty.

@article{Manoir2006EvaluationOT,
  title={Evaluation of the pharmacokinetic profile and analgesic efficacy of oral morphine after total hip arthroplasty.},
  author={B. Du Manoir and Philippe Bourget and Mathieu Langlois and Barbara Szekely and Marc Fischler and Marcel Chauvin and Angelo Paci and Dominique Fletcher},
  journal={European journal of anaesthesiology},
  year={2006},
  volume={23 9},
  pages={748-54}
}
BACKGROUND AND OBJECTIVE Oral morphine may be useful for postoperative pain relief, but few studies have tested its use after in-hospital surgery. METHODS We evaluated clinical efficacy and the pharmacokinetic parameters of oral morphine after total hip arthroplasty. We recruited 60 patients who had total hip arthroplasty under general anaesthesia. The patients were randomized to receive placebo, 10 mg morphine sulphate or 20 mg morphine sulphate orally every 4 h for 24 h. The oral… CONTINUE READING

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