Evaluation of the performance of the reduced local lymph node assay for skin sensitization testing.

@article{Ezendam2013EvaluationOT,
  title={Evaluation of the performance of the reduced local lymph node assay for skin sensitization testing.},
  author={Janine Ezendam and Andr{\'e} Muller and Betty C Hakkert and Henk van Loveren},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2013},
  volume={66 1},
  pages={66-71}
}
The local lymph node assay (LLNA) is the preferred method for classification of sensitizers within REACH. To reduce the number of mice for the identification of sensitizers the reduced LLNA was proposed, which uses only the high dose group of the LLNA. To evaluate the performance of this method for classification, LLNA data from REACH registrations were used and classification based on all dose groups was compared to classification based on the high dose group. We confirmed previous… CONTINUE READING
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