Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish

@article{Takaki2013EvaluationOT,
  title={Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish},
  author={Kevin K. Takaki and John G. Davis and Kathryn Winglee and L. Ramakrishnan},
  journal={Nature Protocols},
  year={2013},
  volume={8},
  pages={1114-1124}
}
Mycobacterium marinum–infected zebrafish are used to study tuberculosis pathogenesis, as well as for antitubercular drug discovery. The small size of zebrafish larvae coupled with their optical transparency allows for rapid analysis of bacterial burdens and host survival in response to genetic and pharmacological manipulations of both mycobacteria and host. Automated fluorescence microscopy and automated plate fluorimetry (APF) are coupled with facile husbandry to facilitate large-scale… CONTINUE READING
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vascular endothelium is a primary target of infectious hematopoietic necrosis virus in zebrafish larvae

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