Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke.

@article{Ranade2005EvaluationOT,
  title={Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke.},
  author={Koustubh Ranade and Todd G. Kirchgessner and Olga A. Iakoubova and James Joseph Devlin and Terrye Delmonte and Priya Vishnupad and Lester E Hui and Zenta Tsuchihashi and Frank M. Sacks and Marc S Sabatine and Eugene E. Braunwald and Thomas jun White and Peter Martin Shaw and Nicholas C. Dracopoli},
  journal={Stroke},
  year={2005},
  volume={36 11},
  pages={
          2346-50
        }
}
BACKGROUND AND PURPOSE The paraoxonases are involved in protecting low-density lipoprotein (LDL) from lipid oxidation. Paraoxonase 1 (PON1) was implicated in susceptibility to coronary artery disease and stroke in previous studies. We evaluated, in a comprehensive way, all 3 paraoxonase genes for association with stroke observed in the Cholesterol and Recurrent Events (CARE) trial. METHODS Over 2500 subjects enrolled in the CARE trial were genotyped for 14 single nucleotide polymorphisms… CONTINUE READING
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