Evaluation of the mutagenicity of simple substituted quinoxalines in Salmonella typhimurium.

@article{Conti2016EvaluationOT,
  title={Evaluation of the mutagenicity of simple substituted quinoxalines in Salmonella typhimurium.},
  author={Luigi Conti and Riccardo Crebelli},
  journal={Drug and chemical toxicology},
  year={2016},
  volume={39 2},
  pages={213-6}
}
Limited information is available on the genotoxicity of simple quinoxalines, distinct from the food related carcinogenic derivatives bearing an aromatic amino group. Isolated positive results, with no apparent structure-activity relationships, were reported in earlier studies on alkyl substituted quinoxalines, raising a safety concern in some regulatory authorities in view of the potential human exposure related to their use as food flavors. In order to elucidate the genotoxic hazard posed by… CONTINUE READING

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