Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii.

@article{Shamon1997EvaluationOT,
  title={Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii.},
  author={L A Shamon and John M Pezzuto and Jewell M. Graves and Rajeshwari R. Mehta and S Wangcharoentrakul and R Sangsuwan and S Chaichana and Patoomratana Tuchinda and P Cleason and Vichai Reutrakul},
  journal={Cancer letters},
  year={1997},
  volume={112 1},
  pages={113-7}
}
Triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii Hook f. (Celastraceae), has been shown to demonstrate potent antileukemic activity in rodent models at remarkably low treatment doses. A variety of other physiological responses are known to be mediated by this compound, including immunosuppressive and antifertility effects. We currently report that triptolide was not mutagenic toward Salmonella typhimurium strain TM677, either in the presence or absence of a… CONTINUE READING

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