Evaluation of the mode of action of mouse lung tumors induced by 4-methylimidazole.

@article{Cruzan2015EvaluationOT,
  title={Evaluation of the mode of action of mouse lung tumors induced by 4-methylimidazole.},
  author={George Cruzan and Jack R Harkema and Hiromi Hosako and Jennifer M Wasil and Francis J Murray},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2015},
  volume={73 2},
  pages={
          501-8
        }
}
4-Methylimidazole (4-MEI) occurs in certain foods and beverages as a product of browning reactions. An increased incidence of lung tumors was reported in mice, but not rats, exposed to levels of 4-MEI in their diet that far exceed human dietary intake. This investigation evaluated the hypothesis that 4-MEI induces mouse lung tumors by the same mode of action (MOA) as styrene: CYP2F2 metabolic activation and increased BrdU labeling. Using styrene (200 mg/kg/day by gavage) as a positive control… CONTINUE READING

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