Evaluation of the mechanisms underlying the kainate-induced impairment of [3H]dopamine release in the rat striatum.

@article{Fedele1993EvaluationOT,
  title={Evaluation of the mechanisms underlying the kainate-induced impairment of [3H]dopamine release in the rat striatum.},
  author={Ernesto Fedele and P Versace and Maurizio Raiteri},
  journal={European journal of pharmacology},
  year={1993},
  volume={249 1},
  pages={71-7}
}
Kainic acid caused a marked decrease of the electrically evoked release of [3H]dopamine from rat striatal slices 4 days after its injection (10 nmol/microliters) into the corpus striatum. This damage was prevented by the non-N-methyl-D-aspartate (non-NMDA) receptor antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX) when co-injected with kainic acid into the striatum. Prior systemic administration of the NMDA selective antagonists (cis-4-phosphonomethyl-2-piperidine carboxylic acid (CGS 19755… CONTINUE READING