Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease.

  title={Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease.},
  author={M{\^o}nica Romero and Ricardo Artigiani and Henrique de Oliveira Costa and Celina Tizuko Fujiyama Oshima and Sender Jankiel Miszputen and Marcello Franco},
  journal={Arquivos de gastroenterologia},
  volume={45 4},
BACKGROUND Crohn's disease accompanied by nonspecific or idiopathic ulcerative proctocolitis corresponds to a condition called intestinal inflammatory disease. The immunoexpression of cyclooxygenase 2 (COX-2) in Crohn's disease becomes more marked with progression of the disease and the presence of wild-type p53 suppresses the transcription of COX-2. AIMS To investigate the immunoexpression of cyclooxygenase 1 (COX-1), COX-2 and p53 in Crohn's ileocolitis and to correlated this expression… CONTINUE READING


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