Evaluation of the hydroxylamine Tempol-H as an in vivo radioprotector.

  title={Evaluation of the hydroxylamine Tempol-H as an in vivo radioprotector.},
  author={Stephen M. Hahn and Murali Cherukuri Krishna and A M Deluca and Deborah Coffin and James B. Mitchell},
  journal={Free radical biology & medicine},
  volume={28 6},
Nitroxides are stable free radical compounds that protect against the toxicity of reactive oxygen species in vitro and in vivo. Tempol (Aldrich, Milwaukee, WI, USA) is a cell-permeable hydrophilic nitroxide and has been shown to be an in vitro and in vivo radioprotector. The limitations of Tempol as a systemic radioprotector are that it causes substantial reductions in arterial blood pressure when administered intravenously and is associated with seizure activity. Furthermore, Tempol is rapidly… CONTINUE READING


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