Evaluation of the hazards of industrial exposure to tricresyl phosphate: a review and interpretation of the literature.

@article{Craig1999EvaluationOT,
  title={Evaluation of the hazards of industrial exposure to tricresyl phosphate: a review and interpretation of the literature.},
  author={Patricia H. Craig and M L Barth},
  journal={Journal of toxicology and environmental health. Part B, Critical reviews},
  year={1999},
  volume={2 4},
  pages={281-300}
}
Commercial tricresyl phosphate (TCP) is a heterogeneous mixture of isomers and aryl phosphate congeners, known for many years to induce delayed neurotoxicity (OPIDN) in humans and experimental animals. In the past the isomer tri-o-cresyl phosphate (TOCP) was thought to be the component primarily responsible for OPIDN. It is now clear that other constituents, particularly the mono-o-esters, are not only neurotoxic but also may be more potent than pure TOCP. As a generality, the toxicity… CONTINUE READING

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