Evaluation of the hairless rat as a model for in vivo percutaneous absorption.

@article{Lauer1997EvaluationOT,
  title={Evaluation of the hairless rat as a model for in vivo percutaneous absorption.},
  author={Andrea C. Lauer and James T. Elder and N. Weiner},
  journal={Journal of pharmaceutical sciences},
  year={1997},
  volume={86 1},
  pages={13-8}
}
Percutaneous absorption of topically applied mannitol and progesterone was compared in vivo with the hairless and hairy rat. Urinary excretion and skin concentration profiles after topical application of mannitol demonstrated that hairless rat skin was a "leakier" barrier to percutaneous absorption of polar compounds than was hairy rat skin, independent of formulation. Liposomal, but not aqueous mannitol was retained in hairy rat skin (> 0.5% after 12 h), whereas only negligible amounts were… CONTINUE READING
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