Evaluation of the genotoxicity of piplartine, an alkamide of Piper tuberculatum, in yeast and mammalian V79 cells.

@article{Bezerra2008EvaluationOT,
  title={Evaluation of the genotoxicity of piplartine, an alkamide of Piper tuberculatum, in yeast and mammalian V79 cells.},
  author={Daniel Pereira Bezerra and Dinara Moura and Renato Moreira Rosa and Marne Carvalho de Vasconcellos and Ana Catarina Romano e Silva and Manoel Odor{\'i}co de Moraes and Edilberto Rocha da Silveira and Mary Anne Sousa Lima and Jo{\~a}o Antonio P{\^e}gas Henriques and Let{\'i}cia V Costa-Lotufo and Jenifer Saffi},
  journal={Mutation research},
  year={2008},
  volume={652 2},
  pages={164-74}
}
The genus Piper belongs to the Piperaceae family, and includes species of commercial and medicinal importance. Chemical studies on Piper species resulted in the isolation of several biologically active molecules, including alkaloid amides, such as piplartine. This molecule, isolated from Piper tuberculatum, has significant cytotoxic activity against tumor cell lines, and presents antifungal, anti-platelet aggregation, anxiolytic, and antidepressant effects. In order to understand the biological… CONTINUE READING